From June 2003 to June 2008 we researched eight major bioindustry companies of natural products in Manaus (Amazonas – Brazil), using the neoschumpeterian methodology. Starting with Amazonian indigenous knowledge and using local and natural raw materials, these companies make innovations and reach for sustainability. Products like natural energetics, anti-infections, anti-inflammatories, etc are made on a natural basis by local and genuinely Amazonian companies.